10 January 2019: GRECO trial has started at Medisch Spectrum Twente

January 2019: First patient included. The first ten inclusions will be followed by direct DSMB monitoring.

22 March 2019: The first monitor visit has been performed at Medisch Spectrum Twente.

25 June 2019: First ten patients are included and trial continuation is approved by DSMB

1 July 2019: The second monitor visit has been performed at Medisch Spectrum Twente

15 September 2019: DSMB analysis of the first 15 patients has been performed, with approved trial continuation

November 2019: Inclusion of first patient in Universitair Medisch Centrum Groningen and VieCuri Venlo

January 2020: DSMB analysis of the first 20 and the first 25 patients has been performed, with approved trial continuation

January 2020: Inclusion of 30th patient in MST, 5th patient in UMCG and 5th patient in VieCuri !

October 2020: DSMB analysis of the first 50 patients has been performed, with approved trial continuation