Inclusion criteria
In order to be eligible to participate in this study a subject must meet the following criteria:

• Age ≥18 years
• Out of hospital cardiac arrest
• Successful cardiopulmonary resuscitation
• Return of spontaneous circulation ≤12 hours ago
• GCS score on admission ≤ 8 or suspected coma in patients who are sedated
• Admission to intensive care unit
• Hemodynamic and respiratory stability as determined by the treating intensive care physician, with the minimum requirement of mean arterial pressure > 65 mmHg. Treatment with inotropes, vasopressors or IABP is allowed.

Of note, cardiac arrhythmia is frequently observed in the patient group under study. Patients with cardiac arrhythmia can be included and with cardiac arrhythmia after inclusion, trial treatment can be continued, unless the treating intensive care physician decides otherwise.

Exclusion criteria
A potential subject who meets any of the following criteria will be excluded from participation in this study:

• Age <18 years
• A known progressive neurological disease
• Expected death within 48 hours

Documents: information forms and informed consent forms.

MST

• Information form patient (Dutch)
• Information form patient - 12 months follow up (Dutch)
• Information form legal representative - short (Dutch)
• Information form legal representative - long   (Dutch)

Rijnstate (Documents coming soon)

UMC Groningen (Documents coming soon)

Vicuri (Documents coming soon)